| CD7 |  |
CD7 antigen is a cell surface glycoprotein of 40 kD expressed on the surface of immature and mature T cells, and natural killer cells. It is the member of immunoglobulin gene superfamily and is the first T cell lineage associated antigen to appear in T cell ontogeny, being expressed in pre-thymic T cell precursors (preceding CD2 expression), and in myeloid precursors in fetal liver and bone marrow, and persisting in circulating T cells. While its precise function is not known, there is recent suggestion that the molecule functions as an Fc receptor for IgM.
CD7 is the most consistently expressed T cell antigen in lymphoblastic lymphomas and leukemias, and is therefore a useful marker in the identification of such neoplastic proliferations. In mature post-thymic T cell neoplasms, it is the most common pan-T antigen to be aberrantly absent and its absence in a T cell population is a useful pointer to a neoplastic conversion.
CD7 is immunoexpressed on 85% of mature peripheral T cells, the majority of post-thymic T cells, NK cells, some myeloid cells, T cell acute lymphoblastic leukemia/lymphoma, acute myelogenous leukemia and chronic myelogenous leukemia. Interestingly, CD7 is conspicuously absent in adult T cell leukemia/lymphoma and is not expressed in Sezary cells.
Mouse Monoclonal, Clone: MRQ-12| | 0.1 ml concentrated | 107M-14 | | | 0.5 ml concentrated | 107M-15 | | | 1 ml concentrated | 107M-16 | | | 1 ml prediluted | 107M-17 | | | 7 ml prediluted | 107M-18 | | | 5 Positive Control Slides | 107S | | |
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