| Cytokeratin 5 |  |
Cytokeratin 5 is an intermediate filament protein of 58 kD molecular wt. amongst the cytokeratin family. It is a type II (Basic) cytokeratin. Antibodies to this protein identify basal cells of squamous and glandular epithelia, myoepithelia, and mesothelium.
Anti-Cytokeratin 5 has been useful in the differential diagnosis of metastatic carcinoma in the pleura versus epithelial mesothelioma. Epithelial mesotheliomas are strongly positive in all cases, but up to 30% of pulmonary adenocarinomas will show focal immunostaining. Almost all squamous cell carcinomas, half of transitional carcinomas, and many undifferentiated large cell carcinomas, and many undiffferentited large cell carcinomas immunostain with CK5. CK5, along with p63, affords a high sensitivity and specificity for squamous differentiation. Myoepithelial cells of the breast, glandular epithelium and basal cells of the prostate are labelled with anti-CK5 antibody. This antibody, along with CK14, has found application in identifying the basaloid phenotype of breast carcinoma, a tumor with poor prognosis. Some carcinomas of ovarian origin may display CK5 positivity.
Rabbit Monoclonal, Clone: EP1601Y| | 0.1 ml concentrated | 305R-14 | | | 0.5 ml concentrated | 305R-15 | | | 1 ml concentrated | 305R-16 | | | 1 ml prediluted | 305R-17 | | | 7 ml prediluted | 305R-18 | | | 5 Positive Control Slides | 305S | | |
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